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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) greater than 27, so long as they also experience weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to quitting smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that features a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of four.1% as opposed to participants who were given placebos) during a 12- month period, while an outside study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed pounds can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you should err on the side of caution and let the FDA do its job and demand some study be done so your public knows the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on the medications.

Researchers found out that participants taking this drug for any year, lost weight within 4 weeks and have kept the body weight off through the entire 56 weeks of the study. Contrave is often a combination from the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which might be made up of many active ingredient, that might make them more efficient and safer.

Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that since right now there are not any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise hypertension and heartbeat, and shouldn't be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.


--Participating in support groups that help the family in the addict recover (for example Al-Anon or Nar-Anon).

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